Lipocalin-2 (NGAL/LCN2), a “help-me” signal in organ inflammation

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Neuronal production of lipocalin-2 as a help-me signal for glial activation.

BACKGROUND AND PURPOSE We explored the hypothesis that injured neurons release lipocalin-2 as a help me signal. METHODS In vivo lipocalin-2 responses were assessed in rat focal cerebral ischemia and human stroke brain samples using a combination of ELISA and immunostaining. In vitro, microglia and astrocytes were exposed to lipocalin-2, and various markers and assays of glial activation were ...

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ژورنال

عنوان ژورنال: Hepatology

سال: 2015

ISSN: 0270-9139

DOI: 10.1002/hep.27930